Therapeutic angiogenesis using autologous adipose-derived regenerative cells in patients with critical limb ischaemia in Japan: a clinical pilot study

T Katagiri, K Kondo, R Shibata, R Hayashida… - Scientific Reports, 2020 - nature.com
… ADRC implantation for therapeutic angiogenesis in patients … progenitor cells show an
increase after ADRC implantation, … angiogenic and cytoprotective effects of ADRC implantation. …

[HTML][HTML] Treatment with adipose-derived regenerative cells enhances ischemia-induced angiogenesis via exosomal microRNA delivery in mice

T Kato, K Kato, Y Shimizu, M Takefuji… - Nagoya Journal of …, 2021 - ncbi.nlm.nih.gov
Implantation of ADRCs improves blood perfusion recovery in CLI states of animals and
humans. Currently, the paracrine effect of ADRCs, including secretion of several growth factors, …

Therapeutic angiogenesis for patients with no-option critical limb ischemia by adipose-derived regenerative cells: TACT-ADRC multicenter trial

Y Shimizu, K Kondo, R Hayashida, K Sasaki… - Angiogenesis, 2022 - Springer
Implantation of adipose-derived regenerative cells (ADRCs) has an angiogenic potential for
… degrees of ischemia that can often delay wound healing and increase amputation risk [1]. …

Human adipose-derived stem cells enriched with VEGF-modified mRNA promote angiogenesis and long-term graft survival in a fat graft transplantation model

F Yu, N Witman, D Yan, S Zhang, M Zhou… - … cell research & therapy, 2020 - Springer
enhanced the viability of implanted hADSCs leading to better … had significantly lower
ischemia-induced necrosis when … capable of attenuating ischemia-induced fibrosis, apoptosis, …

No influence on tumor growth by intramuscular injection of adipose-derived regenerative cells: safety evaluation of therapeutic angiogenesis with cell therapy

J Suzuki, Y Shimizu, K Tsuzuki, Z Pu… - American Journal …, 2021 - journals.physiology.org
… In conclusion, local implantation of ADRCs promotes angiogenesis in response … Implantation
of adipose-derived regenerative cells (ADRCs) augments ischemia-induced angiogenesis. …

Rationale and Design of Therapeutic Angiogenesis by Cell Transplantation Using Adipose-Derived Regenerative Cells in Patients With Critical Limb Ischemia―TACT …

Y Shimizu, K Kondo, Y Fukumoto, M Takamura… - Circulation …, 2020 - jstage.jst.go.jp
… treatment promotes neovascularization and improves major amputation-free survival rates …
rate in participants with therapeutic angiogenesis following ADRC implantation based on our …

The proliferation and differentiation of adipose-derived stem cells in neovascularization and angiogenesis

G Hutchings, K Janowicz, L Moncrieff… - International journal of …, 2020 - mdpi.com
… into both endothelial and smooth muscle cell lines (Figure 1). These … enhance tissue
regeneration by implantation to site of injury. It is believed that this process works by the implanted

Adipose tissue-derived regenerative cells improve implantation of fertilized eggs in thin endometrium

F Yotsumoto, H Iwaguro, Y Harada… - Regenerative …, 2020 - Future Medicine
… Our findings demonstrated that ADRC implantation induced angiogenesis in regenerated …
Implantation of adipose-derived regenerative cells enhances ischemia-induced angiogenesis

Frozen Fat Grafts Maintain Vascular Endothelial Growth Factor Expression and Mediate Angiogenesis During Adipose-Derived Stem Cell Enrichment for Soft Tissue …

CH Lin, CH Tsai, IC Yang, H Ma - Annals of Plastic Surgery, 2022 - journals.lww.com
… with ADSCs resulted in an increase in CD31-positive cells when implanted into the back
of … In our previous study, the administration of ADSCs protected against ischemia-induced

Electrical stimulation promotes the angiogenic potential of adipose-derived stem cells

J Beugels, DGM Molin, DRMG Ophelders, T Rutten… - Scientific reports, 2019 - nature.com
… by post-operative volume loss due to ischemia-induced cell death in the fat graft. Previous …
Implantation of adipose-derived regenerative cells enhances ischemia-induced angiogenesis. …